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Yun-Fei (Frank) Zhu, Ph.D. Founder & Vice President, Chemistry linkedin

Dr. Zhu is a founder of Crinetics. Prior to Crinetics, he was director of chemistry in the endocrinology and metabolism group at Neurocrine Biosciences. At Neurocrine, he led chemistry discovery of nonpeptide GnRH antagonists. His research involved discovery of small molecule inhibitors of several neuropeptide receptors including CRFR2, MCH receptor, and GnRH for the treatment of a range of endocrine diseases. Prior to Neurocrine, he worked at CombiChem and BioResearch. He holds a B.S. in chemistry from Hangzhou University and Ph.D. in organic chemistry from Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.

Relevant Publications

  • Nonpeptide gonadotropin-releasing hormone receptor antagonists.

    Betz SF, Zhu YF, Chen C, Struthers RS. Journal of Medicinal Chemistry. 2008; 51:3331-48.

  • Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor.

    Chen C, Wu D, Guo Z, Xie Q, Reinhart GJ, Madan A, Wen J, Chen T, Huang CQ, Chen M, Chen Y, Tucci FC, Rowbottom M, Pontillo J, Zhu YF, Wade W, Saunders J, Bozigian H, Struthers RS. Journal of Medicinal Chemistry. 2008; 51:7478-85.

  • Design and structure-activity relationships of 2-alkyl-3-aminomethyl- 6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imida zolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists.

    Zhu YF, Guo Z, Gross TD, Gao Y, Connors PJ Jr., Struthers RS, Xie Q, Tucci FC, Reinhart GJ, Wu D, Saunders J, Chen C. Journal of Medicinal Chemistry. 2003; 46:1769-72.

  • Identification of 1-arylmethyl-3- (2-aminoethyl)-5-aryluracil as novel gonadotropin-releasing hormone receptor antagonists.

    Zhu YF, Gross TD, Guo Z, Connors PJ Jr., Gao Y, Tucci FC, Struthers RS, Reinhart GJ, Saunders J, Chen TK, Killam Bonneville AL, Chen C. Journal of Medicinal Chemistry. 2003; 46:2023-6.

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